Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization

Alexander B. Draganov; Ke Wang; Jalisa Holmes; Krishna Damera; Danzhu Wang; Chaofeng Dai; Binghe Wang

doi:10.1039/C5CC05890B

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Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization

Journal article

Peer reviewed

Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization

Alexander B. Draganov, Ke Wang, Jalisa Holmes, Krishna Damera, Danzhu Wang, Chaofeng Dai and Binghe Wang

Chemical communications (Cambridge, England), Vol.51(82), pp.15180-15183

10/21/2015

DOI: https://doi.org/10.1039/C5CC05890B

PMCID: PMC4603419

PMID: 26327521

Abstract or Keywords

click chemistry

boronic acid

bioconjugation

The feasibility of a neighboring boronic acid-facilitated facile condensation of an aldehyde is described. This reaction is bio-orthogonal, complete at room temperature within minutes, and suitable for bioconjugation chemistry. The boronic acid group serves the dual purpose of catalyzing the condensation reaction and being a handle for secondary functionalization.

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Title: Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization
Creators: Alexander B. Draganov - Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
Ke Wang - Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
Jalisa Holmes
Krishna Damera - Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
Danzhu Wang - Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
Chaofeng Dai - Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
Binghe Wang - Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, USA
Publication Details: Chemical communications (Cambridge, England), Vol.51(82), pp.15180-15183
Academic Unit: Natural Sciences Collegium
Language: English
Identifiers: 992684725506111

Click with a boronic acid handle: a neighboring group-assisted click reaction that allows ready secondary functionalization

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